People with type 2 diabetes mellitus and reduced zinc status demonstrated poor glycemic control.

PMID:  J Trace Elem Med Biol. 2017 Dec ;44:132-136. Epub 2017 Jul 12. PMID: 28965568 Abstract Title:  Association of decreased zinc status with poor glycemic control in people with type 2 diabetes mellitus. Abstract:   The study evaluated the relationship between the zinc-related nutritional status and glycemic and insulinemic markers in people with type 2 diabetes mellitus (T2DM). A total of 82 people with T2DM dated between 29 and 59 years were evaluated. The concentration of zinc in the plasma, erythrocytes, and urine was determined by the flame atomic absorption spectrometry process. Dietary intake was assessed using a 3-day 24-h recall. In addition, concentrations of serum glucose, glycated hemoglobin percentage, total cholesterol and fractions, triglycerides, and serum insulin were ascertained. The insulin resistance index (HOMA-IR) andβ-cell function (HOMA- β) were calculated. The markers of zinc status (plasma: 83.3±11.9μg/dL, erythrocytes: 30.1±4.6μg/g Hb, pee: 899.1±622.4μg Zn/24h, and dietary: 9.9±0.8mg/day) were categorized in tertiles and compared to insulinemic and glycemic markers. The results showed that lowerzinc concentrations in plasma and erythrocytes, as well as its own high urinary excretion, were correlated with higher percentages of glycated hemoglobin, representing a worse glycemic control in people with T2DM (p

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