Fasting-mimicking diet Can reverse diabetes

Appears to reverse diabetes, a new research shows.

The fasting-like diet promotes the increase of new insulin-producing pancreatic cells that decrease symptoms of Type 1 and Type 2 diabetes in mice, according to the study on mice and human cells led by Valter Longo, director of the Longevity Institute at the USC Leonard Davis School of Gerontology.

“Cycling a fasting-mimicking diet plus a standard diet basically reprogrammed non-insulin-producing cells to insulin-producing cells,” said Longo, a professor of biological sciences at the USC Dornsife College of Letters, Arts and Sciences.

By triggering the regeneration of cells, the researchers managed to rescue mice and Type 2 diabetes. They reactivated insulin production in cells in Type 1 diabetes patients.

The adult cells and organs prompted a regeneration where damaged cells were replaced with new ones, Longo said.

The analysis published in the journal Mobile is the most current in a string of studies to show promising health advantages of a brief, regular diet that mimics the effects of a water-only fast.

Reversing insulin resistance and depletion

In Type 2 diabetes that is late-stage and also Type 1, the pancreas loses cells, increasing uncertainty in glucose levels. The researchers mimicked Type 1 diabetes in mice by administering high doses of this medication streptozotocin– killing the insulin-producing b-cells — and analyzed mice with Type 2 diabetes, characterized by insulin resistance and eventual loss of insulin production, which have a mutation in the gene Lepr.

The study demonstrated a remarkable reversal of both types of diabetes in mice set on the fasting-mimicking diet for four times. They reduced insulin resistance, regained insulin production and demonstrated levels of blood glucose. This was for mice at the subsequent stages of this illness.

The diet cycles changed on genes in the mice that are active in fetal mice’s growing pancreases. The genes set off production of a protein, neurogenin-3 (Ngn3), thereby generating new, healthy insulin-producing beta cells.

Following steps: clinical study

Longo and his group analyzed pancreatic cell cultures from individual donors and found that, in cells in Type 1 diabetes patients, fasting also improved expression of rapid insulin generation and also their Ngn3 protein. The results imply that a diet can alleviate diabetes .

Longo and his research team have accumulated evidence suggesting health advantages of this fasting-mimicking diet. Their recent study published in Science Translational Medicine revealed that the fasting-mimicking diet reduced risks for diabetes, cancer, cardiovascular disease and other autoimmune ailments in individual study participants who followed the particular diet for five days every month at a three-month interval.

Prior research on the diet have demonstrated potential for relieving symptoms of the disease multiple sclerosis, increasing the effectiveness of chemotherapy for cancer treatments and decreasing fat.

While improving insulin function, Longo noted, these findings warrant a larger FDA trial on the use of the fasting-mimicking diet to treat diabetes patients to help them produce normal levels of insulin.

“Hopefully, people with diabetes may one day be treated with an FDA-approved fasting-mimicking diet for a couple of days per month and gain control over their insulin production and blood glucose,” he said.

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